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Likewise, storage increases the susceptibility of RBCs to necroptosis via NADPH oxidase-derived ROS-dependent RIPK1 activation [201]

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SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103

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The experiments were approved by the Local Ethics Committee