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Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages

Chronic excess can produce an iatrogenic acromegaly phenotype progressive soft-tissue and bone changes in hands, feet and face and contribute to hypertension and cardiac strain

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Furin is a member of the proprotein convertase (PC) family of enzymes, known to process latent precursor proteins into their biologically active state 330

Enzyme specific activity is expressed as mol tetra-guaiacol formed per min per mg protein

The two spike protein subdomains, S1 and S2, are responsible for host cell angiotensin-converting enzyme 2 (ACE2) receptor binding and host cell membrane fusion, respectively 27