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Notably, 35% of Calibrate members who began the program with at-risk waist measurements reached normal levels within 12 months

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Important safety considerations include risk of thyroid C-cell tumors (contraindicated in MEN2 or personal/family history of medullary thyroid carcinoma), pancreatitis, gallbladder disease, hypoglycemia when used with insulin or secretagogues, and potential worsening of diabetic retinopathy in some patients

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