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Clinical Evidence and Safety Data on Combining These Treatments No major randomized controlled trial has exclusively studied semaglutide combined with HRT, but large-scale GLP-1 trials (including SUSTAIN and SELECT) have enrolled women on various hormone therapies without identifying safety signals

Tirzepatide shares an active ingredient with a medication known as Zepbound , which has an FDA approval for helping overweight or obese adults with weight loss and management

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Jones L, Bailey SJ, Rowland SN, et al