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It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile

Protein Kinase C (PKC) is a crucial family of protein kinases and a part of the Mitogen-Activated Protein Kinase (MAPK) family

QTL hotspots were found at Hbb, Hba, Mon1a, and storage-specific Steap3, linking ferroptosis to hemolysis

Because peptides target specific biological systems, they provide a more focused and individualized approach compared to many traditional therapies

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318,319 One study revealed that CP31398 could facilitate the binding of mutant p53 to p53 response elements in vivo and restore the DNA-binding activity of mutant p53 in vitro