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In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)
165 Interestingly, the 5 promoter region of the human CD38 gene contains binding sites for several cytokines, such as TNF, NF-IL6, IL13, and IL4
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Pharmacokinetics of 1 and 2 in vivo: intraperitoneal administration Chemicals and reagents HPLC-grade water was prepared by an in-house PURELAB Option filtration system (Elga lab water solution, UK)
By Michael Dilluvio18 Aug 2025Medically reviewed by Dr
No heating should be required at typical use concentrations
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