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18,25 GLP-1 Agonists: Molecular Design and Pharmacokinetics Evolution of GLP-1 Agonist Structures The potential benefits of natural GLP-1 is constrained by its rapid breakdown by serum enzymes proteases, primarily dipeptidyl peptidase IV (DPP-IV), along with neutral endopeptidase (NEP), plasma kallikrein, and plasmin

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