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This 42% reduction in per-patient expenditure translates to an incremental cost-effectiveness ratio (ICER) of USD 127 per kilogram of weight lost for stepped care versus USD 409 per kilogram for standard approaches

Still, these positive results can be enhanced when in combination with other drugs, such as metformin, which allows for an effective treatment plan with no increase in adverse symptoms usually seen with the treatment of semaglutide alone [121, 122, 125, 126]

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