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AC and JS wrote the first draft of the manuscript

SLN and NLC were differentiated according to the constituents and internal structure, in which SLN (40-1000 nm diametric range) can be stipulated as the 1 st generation of lipid particle matrix after the emulsion which is performing as an alternative of emulsion system

Aug 2021;116(2):505-513

Recent studies showed that ROS acts as second messengers for inflammation activation and play a role in inflammation.6,7 Amlodipine (AML) is a dihydropyridine L-type calcium channel blocker with significant antibacterial activity against several gram-positive and gram-negative strains

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