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FDA guidance for RUO-labeled in vitro diagnostic products explains that RUO labeling is meant to identify materials in a laboratory research phase and distinguish them from diagnostic contexts [16]

Methionine, inositol, and choline are not typically supplemented orally at therapeutic doses in isolation, so the MIC component still adds value even if B12 is covered

Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study

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