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Specifically, KYN primarily restores the diversity of the gut microbiota, whereas ILA and I3C markedly enhance the proliferation of bacteria associated with tryptophan metabolism, such as Akkermansia and Ruminococcus_1

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Defilippis AP, Blaha MJ, Jacobson TA

These colonocytes are known to depend on luminal content for other nutrients (e.g., short-chain fatty acids produced by bacteria are used by the colonocytes for energy production)