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I only rewrote the second section

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Cardiometabolic outcome trials Pooled analysis of Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) 1-5 (assessing semaglutide at lower doses of 0.5 and 1 mg doses for the treatment of T2D), found semaglutide had a similar weight reduction, and glycaemic control, efficacy in older and younger adults

These perturbations lead to the release of mtDAMPs, rewire immune cell metabolism toward pro-inflammatory or immunosuppressive phenotypes, and impair the bioenergetic capacity needed for effective host defense and tissue repair ( Figure 2 )

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Is split dosing the same as microdosing semaglutide