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Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor

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The half-life of GHK-Cu of approximately 12 hours enables sustained activity within the wound milieu

Akin to other structurally characterized MGDs 9,47 , ZZ1-SO 2 H promotes direct target proteinE3 ligase interactions 48 , burying a total surface area of ~350 2

These interactions indirectly modulate various immune signaling pathways, especially RLRs- and TLRs-mediated signaling pathways

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