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Because more free peptide reaches tissues, in vitro receptor-activation studies show that IGF-1 LR3 produces near-maximal IGF-1R phosphorylation at lower molar concentrations than the native ligand [2]

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To have the best effects, various types might need different doses

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Structural analysis together with mutagenesis data revealed mechanisms underlying agonism of different types of GHSR agonists and GHSR-G i coupling