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We also found that auranofin is an efficient inhibitor of pure TGR ( K i = 10 nM), able to kill parasites rapidly in culture at physiological concentrations (5 M), and able to partially cure infected mice (worm burden reductions of ~60%)

GLP-1s, or GLP-1 receptor agonists, are a class of medication that mimics the action of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1)

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