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Joseph Brewer evaluated 112 patients with a prior diagnosis of ME/CFS

Alterations in energy metabolism in cardiovascular diseases often involve systemic pathophysiological changes across multiple systems, while the key energy metabolic targets (AMPK, SIRT) exhibit functional variances in different tissues, suggesting the need for in-depth mechanistic exploration using tissue-specific animal models and expanding clinical research in the future

Time to put down the scalpel

[PMC free article: PMC3836105] [PubMed: 24144653] 66