PMID: 38858523 | doi:10.1038/s41591-024-03018-2 Pasqualotto E et al
121 SpagnuoloC.MocciaS.RussoG
If you store creatine monohydrate properly, its likely still effective after its printed expiration date, as long as you keep it cool and dry
Through molecular docking and molecular dynamics simulations, the binding modes of these natural tyrosinase inhibitors with human tyrosinase (hTYR) and mushroom tyrosinase (mTYR) were systematically explored
For example, by choosing alanine at position 18 instead of arginine in GCG, peptide 20 lost the cation-pi stacking with W215 ECL1 and hydrogen bond with Q204 ECL1 , thereby allowing its outward movement toward ECL1 and leading to the formation of another hydrogen bond (D21 P -I206 ECL1 ) (Fig
But like any powerful treatment, they come with pros and cons