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doi: 10.1016/j.ahj.2020.07.008 13 ClinicalTrials.gov NCT03914326

Lee, J., Miyazaki, M., Romeo, G

Patients with genetic variants associated with robust GLP1R signaling, for example, may achieve target weight loss at lower doses with fewer side effects, while others benefit from more gradual dose escalation or combination therapy with tirzepatide

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Reduces the appearance of dark spots and uneven skin tones

Given the higher risk associated with SO for functional capacity decline, cardiovascular health, and all-cause mortality, it is anticipated that SO may result in more severe public health consequences than obesity alone [10]