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Description

it freely crosses the cell membrane and inhibits UCP2-mediated proton leakage in mitochondria, increases the mitochondrial membrane potential, increases ATP levels, and closes K (ATP) channels without affecting other mitochondrial functions (Zhang et al., 2006)

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Zenobi PD, Guler HP, Zapf J, Froesch ER

This combination is not typically paired with semaglutide, since tirzepatide already covers GLP-1 receptors and the pairing adds redundancy without new pathway coverage

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