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For documented deficiency, loading doses of 1000 mcg daily or several times weekly for 1 to 2 weeks rapidly restore tissue levels

Summary: A hydroxocobalamin B12 injection typically maintains therapeutic levels for approximately 8 to 12 weeks in most patients, which is why maintenance injections are usually given every 2 to 3 months

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Higher-frequency dosing: For advanced schedules, split the daily total across two or more injections rather than one large volume