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GD, Graves' disease

Statements Author contributions TH: Supervision, Visualization, Writing original draft, Formal analysis, Software, Data curation, Funding acquisition, Methodology, Validation, Conceptualization, Resources, Investigation, Project administration, Writing review & editing

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Published in the New England Journal of Medicine in 2023, this phase 2 trial of retatrutide enrolled 338 adults with obesity

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These findings have revealed that NAD+ serves not only as a metabolic cofactor but also as a critical regulator of epigenetic information, linking cellular energy status to long-term gene expression patterns and cellular identity