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Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, Jdar E, Kandler K, Rigas G, Wadden TA, et al

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Users stopping niacinamide typically experience very gradual benefit decline over 1-3 months without dramatic reversal, maintaining 40-60% of improvements long-term if treatment lasted 6+ months, and tolerating breaks or cycling without rebound effects or significant regression concerns

The combined effect of these two aspects ultimately alleviates the phenomenon of muscle atrophy [40]

Written informed consent was obtained from all patients and their guardians

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