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However, the complexities and barriers present in the in vivo environment still present ongoing challenges for the optimal design of peptide-based targeting moieties: (1) Conventional peptide ligands are susceptible to enzymatic barriers

Ehrenreich, H., Degner, D., Meller, J., Brinew, M., Behe, M., Hasselblatt, M., Woldt, H., Falkai, P., Knerlich, F., Jacob, S., von Ahsen, N., Maier, W., Bruck, W., Ruther, E., Cerami, A., Becker, W

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Mutagenicity tests performed in Salmonella typhimurium, Saccharomyces cerevisiae, and Schizosaccharomyces pombeindicate that levocarnitine is not mutagenic