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N Engl J Med 382(18):17081720

However, it is unclear whether the polymorphism of MTHFR could be an independent or an add-on risk factor for specific psychiatric symptoms, such as anxiety, depression, positive, or negative symptoms of schizophrenia, or acts as risk factor for specific psychiatric disorders, such as schizophrenia, major depression, autisms, and bipolar disorders

Cell Cycle (2009) 8:40559

Sekhar, R

NADPH cannot be acquired from extracellular sources but, rather, must be generated by the reduction of NADP + within each cell