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While all three are given as once-weekly subcutaneous injections, the studied dose ranges differ considerably, reflecting differences in potency, receptor activity, and tolerability
aRR, adjusted relative risk
The study looked at the change from baseline in LFC as assessed by MRI-proton density fat fraction (MRI-PDFF) at week 52
Bottom Line Tirzepatide isn't FDA-approved to treat PCOS directly, but its dual-action mechanism makes it a compelling option for people with the condition who are also managing insulin resistance, weight, or obstructive sleep apnea
These effects are modest, but they are at least documented
GLP-3, as a triple agonist targeting GLP-1, GIP, and GCG receptors, holds significant promise as a research compound in the investigation of type 2 diabetesnot only through its observed influence on glycemic parameters but also via its substantial impact on weight reduction
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