doi: 10.3390/ijms26115338
Retatrutide is different because it is designed to target three receptors: GLP-1, GIP, and glucagon
Acts on hypothalamic GLP-1 receptors to reduce food intake and caloric consumption
Tirzepatide is the active ingredient in the injectable medications Mounjaro and Zepbound
These nano-based strategies not only optimize pharmacokinetics and therapeutic efficacy, but also hold potential for non-invasive delivery routes, including oral, buccal, transdermal, and pulmonary administration
But those are different trials with different durations and doses, and cagrilintides strongest data are as the CagriSema combination, so any ranking is a cross-trial inference rather than a proven result