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Common 677CT mutation of the 5,10-methylenetetrahydrofolate reductase gene affects follicular estradiol synthesis

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People who have side effects like nausea when they begin to increase their dose typically stay at the largest dose they can tolerate instead of escalating until hitting the maximum dose as the FDA recommends

If sleep issues extend beyond this window, work with your care team to identify whether nausea or dose timing is the underlying cause, as melatonin alone may mask semaglutide side effects requiring adjustment