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Hormonal changes during pregnancy can also slow digestion, leading to constipation

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Delivery technologies have advanced to include user-friendly devices like the Bydureon BCise autoinjector and other prefilled pen designs for dulaglutide and semaglutide injectable formulations (BYDUREON BCISETM 2017)

Oral (capsule) BPC-157 has animal evidence for gut-local effects because the peptide shows unusual resistance to gastric acid, but human bioavailability data is entirely absent

In this Review, we summarize current preclinical and clinical evidence, showing that the riskbenefit profile of GLP1RAs remains favourable in individuals with T2DM and obesity, although caution is warranted in those with a low cardiometabolic risk, for whom the potential risks of cancer might outweigh any expected benefits