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Following exenatide treatment, the levels of phosphorylated Akt and Bcl-2 were increased, while active caspase-3 expression was decreased

These findings indicated that the sono-activated ZFPG NPs could effectively decrease MDSC levels in the tumor and body, thus alleviating the immunosuppressive TME and enhancing the infiltration and activity of CD8 + T cells in tumors 36