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Mandrika and colleagues (Biochem Pharmacol, 2001, PMID 11239505) examined melanocortin peptides on NF-B DNA binding in RAW 264.7 macrophage-like cells and reported evidence for dual mechanisms of action, and Kannengiesser and colleagues (Inflamm Bowel Dis, 2008, PMID 18092346) reported effects in murine colitis models that were partly independent of MC1R

Practical Advice Consult a Professional: Its crucial to work with your healthcare provider (such as your team at MHM Medical Group) to determine which supplements, if any, are right for you, especially when taking prescription medications

However: Broad energy, immune, or anti-aging claims are not universally supported by high-level clinical evidence

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