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Oxidative stress significantly accelerates the telomere shortening and ageing of chondrocytes (Brandl et al., 2011)
Oral glutathione bioavailability is very limited
Given that the gut-host interaction is necessary for the maintenance of normal host physiological functions and the considerable evidence implying its role in the pathogenesis of a myriad of diseases including CVD 9 , we sought to provide a mechanism by which dysregulated gut homeostasis due to BoCA consumption could drive cardiovascular dysfunction
NAPDH Oxidase converts oxygen to Super Oxide (O 2 ) mainly in neutrophils Myeloperoxidase (MPO) converts peroxide (H2O2) into Hydrochloric Acid (HOCl) mainly in neutrophils Fenton Reaction generates Hydroxide (OH-) from peroxide (H2O2) using iron Superoxide Dismutase (SOD) converts Super Oxide (O 2 ) to peroxide (H2O2) Glutathione convert Hydroxide (OH-) to water Catalase converts Peroxide (H2O2) to water We will see in the immunology section that that a defect in NADPH Oxidase causes Chronic Granulomatous disease
Together, we will explore whether Ozempic or other GLP-1-based therapies are suitable solutions tailored to your individual health, lifestyle, and wellness goals