nad+ mots-c and 5-amino-1mq / / blend NAD+/MOTS-c/5-Amino-1MQ Dosing : r/BodyHackGuide 5-Amino-1MQ Peptide Dosing Guide: Oral – 5-Amino 1MQ Capsules | A

When NNMT runs too high in fat tissue, it wastes a form of vitamin B3 that the body needs to make NAD+

In regards to its effect on mitochondria, clinical studies have shown that it can stimulate mitochondrial biogenesis, leading to an increase in the number and function of mitochondria within cells (Yue et al., 2022)

The Babula 2024 mouse study saw clear fat-mass reduction at 28 days, which scales roughly to 610 weeks in humans

The logic is solid, though it's worth noting this is a community-derived protocol, not a studied stack

Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

Most people running it describe the effect as "things just working a bit better" particularly for visceral fat reduction that plateaued on GLP-1 therapy alone