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In the New England Journal of Medicine, Garvey and colleagues [5] report the results of the REDEFINE 1 trial, a 68-week, phase 3a double-blind, placebo-controlled and active-controlled trial evaluating the efficacy and safety of coadministered cagrilintide and semaglutide in adults with obesity [body mass index (BMI) 30 kg/m 2 ] or overweight (BMI 27 kg/m 2 ) with at least one weight-related comorbidity
Bibliography Pickart L, Margolina A (2018)
It is often the missing piece for people who want visible changes, not just lower numbers
For those unfamiliar with why this happens, the discomfort can feel alarming and lead to premature discontinuation of an otherwise well-designed protocol
Uncertain Mechanisms Although numerous signalling pathways have been proposed, researchers have not identified one definitive mechanism explaining all observed effects
Pellets run about $700 each, twice a year
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