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Medical and Pharmacological Options Metformin Metformin is an insulin-sensitising medication originally developed for type 2 diabetes, which is now being widely used in PCOS management

GLP-1 receptor agonist medications mimic this natural hormone to help with weight loss and blood sugar management through multiple mechanisms

Numbness or Tingling (Carpal TunnelLike Symptoms) Elevated GH levels may affect nerve tissues, leading to paresthesia (tingling, numbness) in the hands or wrists similar to carpal tunnel syndrome

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Both heterozygous patients with partial pathway impairment and homozygous patients with complete LOF mutations achieve clinically significant weight reduction (approximately 5%-10% from baseline) and experience marked reductions in hyperphagia

Key Takeaway: Semaglutide addresses the physical need to eat (homeostatic hunger), while naltrexone addresses the psychological desire or pleasure associated with eating (hedonic hunger)