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Craving and increased motivation to seek alcohol often occur after reexposure to alcohol or an alcohol-associated cue, which may induce relapse or reinstatement

Mechanistically, acetyl-CoA, a derivative of BCKAs, inhibits the interaction between PR domain-containing protein 16 (PRDM16) and peroxisome proliferator-activated receptor- (PPAR-) by acetylating the k915 site of PRDM16 to maintain WAT characteristics

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This albumin-binding confers a depot effect, allowing for sustained drug release and extended systemic exposure

See a specialist for accurate diagnosis and targeted treatment