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Moreover IR in PCOS was shown to destroy the effect of gonadotropins, enhance the sensitivity of follicular membrane cells to the luteinizing hormone, and increase the expression of P450c17 and 3-hydroxysteroid dehydrogenase type 2, leading to increased production of androgen (152)
Recently, glucagon-like peptide 1 receptor agonists (GLP- 1RAs) have emerged as safe and effective treatments for diabetes and obesity
Retatrutide is an investigational weight loss injection given once weekly
Disclaimer: For laboratory and research purposes only
Important issues remain, from tolerability and cost to the need for chronic treatment and weight regain after discontinuation
These medications lower blood sugar by enhancing insulin release, reducing glucagon secretion, and slowing the emptying of the stomach
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