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There is no human head-to-head bioavailability trial declaring one route superior, so pick the route your protocol specifies and hold it consistently

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It is photoprotection adherence

Burns et al., 1993

For at-home use, 0.250.5 mm is generally considered safe

5.1.1 DNA methylation alterations 5.1.1.1 Aberrant imprinting and global hypomethylation Critical imprinting regions undergo substantial methylation changes following EED exposure