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By synthesizing and testing known HLA ligands and experimental counterparts containing a single UAA at one or more selected binding positions, the authors will establish the magnitude of impact that a given mutation can have on HLA binding
Management of relapsed ovarian cancer: a review
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While the precise mechanism for the disruption of the ligand-binding interaction between these two proteins is not defined, the presence of an aggregation of GST monomers following oxidative stress implicates intermolecular disulfide bridge formation between available cysteine residues
