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It was first isolated from alpha-MSH, where it occupies positions 11 through 13, the minimum fragment required for anti-inflammatory signaling
Guerville F, De Souto BP, Ader I, Andrieu S, Casteilla L, Dray C, Fazilleau N, Guyonnet S, Langin D, Liblau R (2020) Revisiting the hallmarks of aging to identify markers of biological age
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Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes
These potential synergies indicate that H could be strategically integrated as an adjunct to existing treatment regimens, enhancing neuroprotection and functional outcomes
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