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Vitamin B12 absorption from food requires several steps: intrinsic factor secretion from gastric parietal cells, acid-dependent release of B12 from food proteins, and physical contact time in the ileum where transcobalamin receptors capture the B12-intrinsic factor complex
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The introduction of nasal spray delivery of peptides is associated with improved bioavailability, shorter latency to physiological levels, and lower inter-dose variability
In practice, injections are used when rapid correction or assured absorption is needed
S2CID 73781536
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