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Kragstrup said he and his team became interested in GLP-1-based therapies because experimental studies suggest that they may have direct anti-inflammatory and tissue-protective effects in joint disease

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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

These effects are dose-dependent and align with its unique receptor pharmacology and optimized pharmacokinetics