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When NNMT is active, it methylates nicotinamide (a form of vitamin B3), making it unavailable for conversion into NAD a crucial molecule for energy production and cellular repair

Kraus et al., Nature (2014), on NNMT and diet-induced obesity

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[3] Additionally, NAD+ has been investigated for improving metabolic health, possibly benefiting conditions like metabolic syndrome by supporting better insulin sensitivity and mitochondrial function

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