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FIGURE 2 3.6 Oxidative stress indices Adenine and STZ induced a significant increase in 8-OHdG, 8-isoprostane, and AGEs (Figure 3), an effect that was significantly attenuated by all the treatment combinations, but it was more pronounced with the GAmelatoninbetaine combination
Patchett AA, Nargund RP, Tata JR, et al
ROS accumulation will damage to DNA, protein and lipid, thus promoting genetic instability and tumorigenesis [45,46,47]
Several neuroimaging and postmortem studies have shown a loss of neuronal and glial population in the cingulate cortex, prefrontal cortex (PFC) (11) and hippocampus (12, 13) of depressed subjects (Figure 1) (14, 15)
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