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2019 Apr 26;11(5):952

The SURMOUNT-1 trial showed that participants receiving the highest dose of tirzepatide (15 mg) lost an average of 22.5% of their body weight over 72 weeks

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In a single internally consistent radioligand series measuring inhibition of I-NDP-alpha-MSH binding to membranes from BHK570 cells stably expressing each human receptor, bremelanotide returned Ki values of 0.25 nM at MC4R, 6.4 nM at MC1R, 17 nM at MC5R and 53 nM at MC3R, corresponding to pKi 9.6, 8.2, 7.8 and 7.3 respectively