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Acute kidney injury (AKI), a common complication with an incidence between 2057% in patients with decompensated liver disease, is often a precursor to CKD. Early detection and optimal management are crucial since serum creatinine is a late indicator of kidney injury

More mechanistic work shows that intravenously delivered AD-MSCs blunt granulosa-cell apoptosis, curtail senescence markers (SA--gal) and normalise FSH and AMH by suppressing over-active PI3K/AKT/mTOR signalling in acute and chronic cyclophosphamide rat models, highlighting a conserved anti-ageing pathway [177]

This makes it comparatively safer, though research gaps remain

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