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Malondialdehyde, a marker of lipid peroxidation (Gutteridge, 1995) showed a significant decrease in brain by the highest dose of cannabis, suggesting an antioxidant effect for the extract

Metformin activates AMPK/SIRT1/NF-B pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

For this reason, a relatively high starting concentration was needed to reliably induce the phenotype being studied

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