Such combination has proven its efficacy on surrogate endpoints
Targeting EZH2 in cancer
The Expanding Scope of GLP-1 Receptor Agonists: Six Uses Beyond Diabetes
Bjarnason, I., Scarpignato, C., Holmgren, E., Olszewski, M., Rainsford, K
In the pivotal trials [of Viagra], the overall response rate was about 70 percent, but in the real world its closer to 50 percent. He added, Theres room for improvement in efficacy, especially in subpopulations like diabetics or post-nerve sparing radical prostatectomy patients. Many patients also find the timing and preparation required for PDE5 inhibitors such as waiting periods, taking them on an empty stomach, or coordinating with infrequent sexual activity disruptive to intimacy
Nuic B, Bowden A, Rombenso A, Salini M, Jago MK, Smullen R, Franklin CE, Cramp RL