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Results GSH synthesis is required for the survival of adult animals To better understand the importance of GSH in adult mammals, we developed an inducible, whole-body Gclc KO mouse by breeding the Gclc f/f mouse strain 30 with the Rosa26-CreERT2 mouse strain 31

Alkali burns elevate ROS levels, upregulating the expression of genes such as Nox2, Nox4, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)

There are many short-term clinical trials on the effect of oral tranexamic acid, but there is not enough data on long-term effects yet

High expression of GT provides cells with greater quantities of cysteine through the breakdown of extracellular GSH (Gerber and Thung, 1980

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The cell detection tool was used on the DAPI channel to make sure that only a cell was recognised and not the background or artefact by system