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Studies examining cortisol, growth hormone, and other pituitary hormones have generally not demonstrated clinically significant direct effects, though data are limited

A hypothesis concerning the pathogenesis

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doi: 10.1371/journal.pone.0176715 43 YangMLiuSCaiJSunXLiCTanMet al

This leads to actual disruptions in skin cell activity and structure, which causes inflammation and even cell DNA damage