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PMID: 2555512 PMC1572913 Pigmentation Pathway (MC1R, Preclinical) Eumelanin upregulation via cAMP / MITF / tyrosinase axis MC1R activation by melanocortin agonists is reported to raise intracellular cAMP, upregulate MITF, and increase tyrosinase-mediated eumelanin synthesis in epidermal melanocyte models

Further, it is unclear how the ||||||||| |||||||||| || |||||||| ||||||| |||| |||||| |||||| ||||| |||| |||||||| ||| |||||||| || ||||||||||| ||||||||||||| ||| ||||||||| || ||| ||||| ||||| ||| ||||||||||||| ||| || ||||||| ||||||| |||||||||||||||| |||||||| |||||||| |||| |||||||||| A sensitivity analysis was also conducted to assess the impact of including studies |||| ||| ||||||||||||| ||||| ||| |||| || | ||||||| ||||||| || ||||||||||||||| ||| |||||||||| |||||||| ||||||||| |||| ||||||||| ||||| |||||| ||| || ||| ||| || |||||| ||||||| ||||||| Reporting of methods was ||| ||||||||||||| || ||||||| || ||| |||||||| ||||||| ||| ||| ||||||||| |||||| || ||||||||||| || |||||| ||| |||||| || |||| || ||||| ||||||||||| |||||||| || ||||||| ||| |||||| || ||||||| ||||||| |||| ||| |||||||||| Other Relevant Evidence This section includes submitted long-term extension studies and additional relevant studies included in the sponsors submission to CADTH that were considered to address important gaps in the evidence included in the systematic review

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